DNA Test: Celiac Disease

The genetic tes, or DNA test, consists of a buccal swab or the collection of the oral mucosa to be carried out by crawling the swab, which you will find around the package, under the tongue or inside the cheek.

DNA testing is very simple and fast. Once the withdrawal is made, just communicate the presence of the sample ready to send to the number that you will find in the instructions inside the package and you will be contacted by a courier for the collection of the same.

The report will be sent to you by email within 15 days.

CELIAC

Celiac disease, or autoimmune gluten enteropathy, is a permanent intolerance to gluten contained in wheat, barley, spelled, rye and oat flours. Genetic testing allows the diagnosis of celiac disease.

The main genetic risk factors are specific haplotypes (allelic combinations) of HLA class II genes of the major histocompatibility complex (HLA-DQ2 and HLA-DQ8).  DQ2 and DQ8 are glycoproteins, formed by two chains (Alpha and beta) encoded by the DQA1 and dqb1 genes, respectively. The DQA1*05 and DQB1*02 alleles encode for DQ2 at higher risk of celiac disease, while the DQA1*03 and DQB1*03:02 alleles for DQ8 at lower risk of celiac disease.

GENERAL, PREPARATION

The correct collection of the oral mucosa sample requires cleaning the oral cavity (brush your teeth or rinse your mouth a few minutes first) to avoid food residues that may remain adherent to the swab.

The test can also be carried out on newborns.